Mary Musgrove belonged to the Creek tribe. Her mother was a Creek. Her father was a settler from South Carolina. Her Creek name was Coosaponakesee. She knew how to speak both English and the Creek language.

Mary was 16 when she married John Musgrove. His job was a trader. They opened a trading post near the Savannah River. The Creeks and colonists used the trading post to shop and sell their goods.

In 1733, General John Oglethorpe landed in Savannah to start the Colony of Georgia. Mary Musgrove became an interpreter for John Oglethorpe. Mary helped him talk to Tomochichi. Tomochichi was the Creek Chief. Mary helped Oglethorpe write treaties between the Native Americans and colonists. Both groups of people trusted her. Mary Musgrove was the key to the peaceful beginning of the city of Savannah and the Colony of Georgia.

Mary Musgrove played a very important part in starting the Georgia Colony. In 1993, she was named a Georgia Woman of Achievement.